S100A12

Across TCGA pan-cancer cohorts, S100A12 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of S100A12’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where S100A12 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types S100A12 is over-expressed in tumor, although a few such as LIHC and LUAD show the opposite, repressed pattern.

KIRC, LIHC, and LUAD are the cancer types where S100A12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in S100A12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.200	<.001	11	view →
LIHC	Male	All	−1.146	<.001	8	view →
LUAD	Male	All	−2.013	<.001	7	view →
KICH	All	II,III,IV	−1.294	<.001	7	view →
BRCA	All	III,IV	−0.903	<.001	6	view →
STAD	Male	II,III,IV	−2.369	<.001	4	view →
LUSC	All	All	−0.984	.010	2	view →
CHOL	All	All	−0.900	.008	2	view →
KIRP	All	II,III,IV	−0.568	.025	2	view →
PRAD	All	All	−0.453	.007	2	view →
BLCA	Female	IV	−1.693	.023	1	view →
THCA	All	All	−0.247	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

S100A12–KIRC

Open the KIRC breakdown →