S100A12

Across TCGA pan-cancer cohorts, S100A12 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated S100A12 data layer compared with 3 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher S100A12 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated S100A12 expression acts as an unfavorable survival marker, although some lineages such as MESO and LUSC show a favorable association.

LUAD, STAD, and SCLC are the cancer types where S100A12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.743	0.836	<.001	59	view →
STAD	DFS	Tertile	All	0.570	0.708	.007	40	view →
SCLC	OS	Tertile	All	0.570	0.783	.012	36	view →
MESO	DFS	Median	All	0.485	0.293	.005	30	view →
COAD	DFS	Quartile	III,IV	0.231	0.594	.008	25	view →
LUSC	DFS	Median	III,IV	0.900	0.223	.001	22	view →
GBM	OS	Median	All	0.346	0.477	.008	19	view →
SKCM	OS	Tertile	All	0.829	0.911	.001	15	view →
BRCA	DFS	Quartile	III,IV	0.804	0.930	.008	14	view →
ACC	OS	Quartile	II,III,IV	0.792	1.000	.010	13	view →
READ	DFS	Median	IV	0.179	0.936	.010	10	view →
KIRP	DFS	Tertile	IV	0.046	0.528	.026	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

S100A12–LUAD (DFS)

Open the LUAD breakdown →