RXFP4

Across TCGA patient cohorts, RXFP4 mutation is significantly associated with the RNA expression of many other genes, with 682 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RXFP4-associated genes across cancer lineages are HSFY4P, RNMTL1P1, and NDUFA5P12. Each is linked with RXFP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RXFP4-to-partner and partner-to-RXFP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSFY4P grouped by RXFP4-low versus RXFP4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP4→partner) and Y-score (partner→RXFP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	HSFY4P →	+0.029	+4.691	.001	.001	3	2
BLCA	RNMTL1P1 →	+0.100	+4.704	<.001	.005	3	2
BLCA	NDUFA5P12 →	+0.190	+3.758	<.001	.008	3	2
LUSC	DNAJC19P4 →	+0.206	+4.984	.003	.009	3	2
SKCM	RNU6-1318P →	+0.273	+3.877	<.001	.003	3	2
UCEC	TMEM138 →	+0.354	+3.711	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 682 associations by consensus.

HSFY4P by RXFP4 expression — BLCA

Explore this box plot interactively →