RXFP4

Across TCGA pan-cancer cohorts, RXFP4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RXFP4 data layer compared with 4 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RXFP4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RXFP4 expression acts as an unfavorable survival marker, although some lineages such as SKCM and BLCA show a favorable association.

LIHC, SKCM, and BLCA are the cancer types where RXFP4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.464	0.610	<.001	59	view →
SKCM	DFS	Quartile	II,III,IV	0.885	0.642	.004	32	view →
BLCA	OS	Quartile	All	0.805	0.637	.005	31	view →
LUAD	OS	Median	II,III,IV	0.398	0.164	.002	22	view →
ACC	OS	Median	III,IV	0.616	0.853	.029	19	view →
ESCA	DFS	Quartile	All	0.118	0.568	.038	15	view →
CHOL	DFS	Tertile	II,III,IV	0.140	0.645	.026	12	view →
CESC	DFS	Median	All	0.773	0.868	.007	10	view →
THCA	DFS	Median	III,IV	0.854	0.979	.012	9	view →
UVM	OS	Tertile	III,IV	0.194	0.697	.008	9	view →
DLBC	DFS	Quartile	III,IV	1.000	0.134	.008	7	view →
HNSC	OS	Tertile	III,IV	0.717	0.578	.028	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RXFP4–LIHC (DFS)

Open the LIHC breakdown →