RUVBL1

Across TCGA patient cohorts, RUVBL1 protein abundance is significantly associated with the RNA expression of many other genes, with 14,643 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RUVBL1-associated genes across cancer lineages are FAM86JP, CCDC58, and UMPS. Each is linked with RUVBL1 in more than 7 cancer types. Because this analysis shows association rather than direction, both RUVBL1-to-partner and partner-to-RUVBL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RUVBL1 versus FAM86JP in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUVBL1→partner) and Y-score (partner→RUVBL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM86JP →	+1.018	+0.330	<.001	<.001	3	8
LSCC	CCDC58 →	+0.815	+0.317	<.001	<.001	3	8
LSCC	UMPS →	+0.773	+0.306	<.001	<.001	3	7
LSCC	MRPL3 →	+0.757	+0.300	<.001	<.001	3	7
LSCC	TRMT10C →	+0.681	+0.324	<.001	<.001	3	7
LSCC	RFC4 →	+0.815	+0.250	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,643 associations by consensus.

RUVBL1 vs FAM86JP — LSCC

Explore this scatter interactively →