RUVBL1

Across TCGA pan-cancer cohorts, RUVBL1 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of RUVBL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RUVBL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RUVBL1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, COAD, and BLCA are the cancer types where RUVBL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RUVBL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.795	<.001	11	view →
COAD	Female	II,III,IV	+1.730	<.001	11	view →
BLCA	All	III,IV	+1.330	<.001	11	view →
LUAD	Male	All	+0.938	<.001	11	view →
STAD	Male	II,III,IV	+1.305	<.001	9	view →
LIHC	Male	All	+1.210	<.001	9	view →
LUSC	Male	II,III,IV	+1.636	<.001	8	view →
THCA	All	All	−0.171	.003	8	view →
READ	All	II,III,IV	+1.295	<.001	7	view →
BRCA	All	III,IV	+0.940	<.001	6	view →
CHOL	Male	All	+2.526	<.001	5	view →
KICH	Female	All	−0.982	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

RUVBL1–HNSC

Open the HNSC breakdown →