RUVBL1-AS1

Across TCGA pan-cancer cohorts, RUVBL1-AS1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of RUVBL1-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RUVBL1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RUVBL1-AS1 is over-expressed in tumor, although a few such as BRCA and THCA show the opposite, repressed pattern.

HNSC, BLCA, and BRCA are the cancer types where RUVBL1-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RUVBL1-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.166	.005	3	view →
BLCA	All	All	+0.159	.037	2	view →
BRCA	All	III,IV	−0.155	.026	2	view →
THCA	All	All	−0.058	.015	2	view →
KIRP	Female	All	+0.206	.028	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

RUVBL1-AS1–HNSC

Open the HNSC breakdown →