RUNX2

Across TCGA patient cohorts, RUNX2 protein abundance is significantly associated with the RNA expression of many other genes, with 6,434 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RUNX2-associated genes across cancer lineages are PCOLCE, COL5A1, and CTHRC1. Each is linked with RUNX2 in more than 6 cancer types. Because this analysis shows association rather than direction, both RUNX2-to-partner and partner-to-RUNX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RUNX2 versus PCOLCE in OV, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX2→partner) and Y-score (partner→RUNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PCOLCE →	+1.032	+0.413	<.001	<.001	3	6
CCRCC	COL5A1 →	+3.622	+1.159	.009	.003	2	7
OV	CTHRC1 →	+1.419	+0.462	<.001	<.001	3	6
OV	FBN1 →	+1.637	+0.469	<.001	<.001	3	6
OV	MMP2 →	+2.043	+0.570	<.001	<.001	3	6
OV	ITGA11 →	+1.709	+0.537	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,434 associations by consensus.

RUNX2 vs PCOLCE — OV

Explore this scatter interactively →