RUNX2

Across TCGA pan-cancer cohorts, RUNX2 RNA is linked to patient survival in 32 of 34 cancer types, making it the most broadly survival-associated RUNX2 data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher RUNX2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RUNX2 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUAD show a favorable association.

KICH, UVM, and BLCA are the cancer types where RUNX2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.626	1.000	<.001	96	view →
UVM	DFS	Median	All	0.422	0.750	<.001	88	view →
BLCA	OS	Tertile	All	0.529	0.701	<.001	76	view →
STAD	DFS	Tertile	All	0.314	0.547	.003	64	view →
SKCM	OS	Median	II,III,IV	0.372	0.229	<.001	62	view →
ACC	DFS	Median	III,IV	0.268	0.612	.004	56	view →
LUAD	DFS	Tertile	III,IV	0.629	0.173	<.001	54	view →
LGG	DFS	Median	All	0.646	0.826	<.001	51	view →
MESO	OS	Tertile	All	0.284	0.522	.003	49	view →
CESC	DFS	Quartile	III,IV	0.107	0.930	.001	42	view →
KIRC	OS	Quartile	All	0.530	0.754	<.001	38	view →
COAD	DFS	Median	All	0.698	0.857	<.001	38	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 32 lineages.

RUNX2–KICH (OS)

Open the KICH breakdown →