RUNX2

Across TCGA patient cohorts, RUNX2 mutation is significantly associated with the RNA expression of many other genes, with 4,835 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX2-associated genes across cancer lineages are LINC01939, RNA5SP423, and SYPL1P1. Each is linked with RUNX2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RUNX2-to-partner and partner-to-RUNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC01939 grouped by RUNX2-low versus RUNX2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX2→partner) and Y-score (partner→RUNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC01939 →	+0.534	+3.468	<.001	.005	3	4
LUSC	RNA5SP423 →	+0.558	+4.412	<.001	.006	3	3
UCEC	SYPL1P1 →	+0.073	+1.994	<.001	.006	3	3
UCEC	LINC02438 →	+0.624	+3.000	<.001	<.001	3	3
UCEC	RNA5SP413 →	+1.074	+1.736	<.001	.002	3	3
SKCM	LINC02350 →	+0.069	+3.159	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,835 associations by consensus.

LINC01939 by RUNX2 expression — LUAD

Explore this box plot interactively →