RUNX2

Across TCGA patient cohorts, RUNX2 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX2-associated genes across cancer lineages are Shc_pY317, ASNS, and NF2. Each is linked with RUNX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUNX2-to-partner and partner-to-RUNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by RUNX2-low versus RUNX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX2→partner) and Y-score (partner→RUNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.232	-2.906	<.001	.001	3	3
UCEC	ASNS →	+0.275	+1.700	.043	.042	3	3
STAD	NF2 →	+0.192	+3.000	.019	.034	3	2
STAD	CD31 →	-0.189	-3.169	.013	.019	3	2
STAD	Claudin-7 →	+0.702	+3.169	.030	.019	3	2
UCEC	EGFR_pY1068 →	-0.290	-2.662	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Shc_pY317 by RUNX2 expression — UCEC

Explore this box plot interactively →