RUNX2

Across TCGA cell cohorts, RUNX2 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUNX2-associated genes across cancer lineages are OR8D1, OR8B3, and OR8B4. Each is linked with RUNX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNX2-to-partner and partner-to-RUNX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8D1 grouped by RUNX2-low versus RUNX2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX2→partner) and Y-score (partner→RUNX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR8D1 →	+0.046	+3.584	<.001	.008	3	2
OESOPHAGUS	OR8B3 →	+0.020	+3.392	<.001	.007	3	2
LUNG_NSCLC_LUAD	OR8B4 →	+0.032	+4.472	<.001	.001	3	2
OESOPHAGUS	IL17F →	+0.036	+3.836	<.001	.004	3	1
SKIN	HTR3C →	+0.053	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR51Q1 →	+0.103	+3.866	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

OR8D1 by RUNX2 expression — OESOPHAGUS

Explore this box plot interactively →