RUBCN

Across TCGA cell cohorts, RUBCN mutation is significantly associated with the RNA expression of many other genes, with 122 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUBCN-associated genes across cancer lineages are WDR72, ZAN, and KRTAP5-4. Each is linked with RUBCN in more than 1 cancer types. Because this analysis shows association rather than direction, both RUBCN-to-partner and partner-to-RUBCN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, WDR72 grouped by RUBCN-low versus RUBCN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUBCN→partner) and Y-score (partner→RUBCN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	WDR72 →	+1.491	+3.212	.005	.006	3	2
SOFT_TISSUE	ZAN →	+0.006	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP5-4 →	+0.028	+5.369	<.001	.004	3	1
SOFT_TISSUE	TARM1 →	+0.052	+5.369	<.001	.004	3	1
SOFT_TISSUE	CT45A6 →	+0.022	+5.369	<.001	.004	3	1
SKIN	PAX4 →	+0.023	+3.882	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 122 associations by consensus.

WDR72 by RUBCN expression — LARGE_INTESTINE

Explore this box plot interactively →