RUBCN

Across TCGA pan-cancer cohorts, RUBCN RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated RUBCN data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RUBCN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RUBCN expression acts as an unfavorable survival marker, although some lineages such as KIRC and ESCA show a favorable association.

LIHC, KIRC, and UCEC are the cancer types where RUBCN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.432	0.583	<.001	52	view →
KIRC	DFS	Median	All	0.881	0.710	.001	42	view →
UCEC	DFS	Median	All	0.558	0.725	<.001	32	view →
ESCA	OS	Median	All	0.795	0.598	.001	30	view →
MESO	OS	Quartile	IV	0.158	0.808	.002	24	view →
LUSC	DFS	Quartile	III,IV	0.485	0.786	.002	22	view →
OV	OS	Tertile	III,IV	0.793	0.888	.010	20	view →
ACC	DFS	Median	II,III,IV	0.174	0.575	.010	19	view →
SCLC	OS	Quartile	All	0.559	0.255	.010	13	view →
BLCA	DFS	Quartile	All	0.157	0.510	.006	12	view →
COAD	DFS	Median	III,IV	0.296	0.543	.021	9	view →
PRAD	OS	Median	All	0.803	0.917	.014	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

RUBCN–LIHC (OS)

Open the LIHC breakdown →