RTN4R

Across TCGA cell cohorts, RTN4R mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTN4R-associated genes across cancer lineages are KRTAP1-1, LRRTM3, and GHR. Each is linked with RTN4R in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN4R-to-partner and partner-to-RTN4R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP1-1 grouped by RTN4R-low versus RTN4R-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN4R→partner) and Y-score (partner→RTN4R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KRTAP1-1 →	+0.136	+5.969	<.001	.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.006	+5.539	<.001	.003	3	1
LARGE_INTESTINE	GHR →	+0.501	+3.295	.002	.009	3	1
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	SEMG2 →	+0.551	+3.141	<.001	.002	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.377	+3.035	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

KRTAP1-1 by RTN4R expression — BLOOD_Leukemia

Explore this box plot interactively →