RTN4R

Across TCGA pan-cancer cohorts, RTN4R RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RTN4R data layer compared with 4 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher RTN4R RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RTN4R expression acts as an unfavorable survival marker, although some lineages such as LGG and SCLC show a favorable association.

UVM, KIRC, and HNSC are the cancer types where RTN4R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.413	0.728	<.001	87	view →
KIRC	DFS	Median	All	0.827	0.915	<.001	84	view →
HNSC	OS	Median	All	0.465	0.718	<.001	74	view →
ACC	DFS	Quartile	All	0.208	0.739	<.001	73	view →
LGG	OS	Median	All	0.531	0.340	<.001	45	view →
CESC	DFS	Median	All	0.777	0.864	.008	32	view →
PAAD	OS	Tertile	All	0.336	0.585	.013	19	view →
SCLC	OS	Quartile	II,III,IV	0.731	0.274	.002	18	view →
UCS	DFS	Tertile	IV	0.323	0.942	.024	18	view →
LUSC	DFS	Quartile	III,IV	0.478	0.816	.002	18	view →
DLBC	DFS	Median	II,III,IV	0.890	0.509	.011	15	view →
LAML	DFS	Quartile	All	0.659	0.275	.023	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RTN4R–UVM (DFS)

Open the UVM breakdown →