RTN1

Across TCGA patient cohorts, RTN1 mutation is significantly associated with the RNA expression of many other genes, with 5,149 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN1-associated genes across cancer lineages are ZWINT, DVL2, and NCKIPSD. Each is linked with RTN1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RTN1-to-partner and partner-to-RTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZWINT grouped by RTN1-low versus RTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN1→partner) and Y-score (partner→RTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZWINT →	+0.852	+2.115	<.001	<.001	3	5
UCEC	DVL2 →	+0.575	+1.847	<.001	<.001	3	5
UCEC	NCKIPSD →	+0.400	+2.436	<.001	.001	3	5
SKCM	VDAC2 →	+0.397	+2.273	<.001	.004	3	4
UCEC	PRPF4 →	+0.534	+2.454	<.001	<.001	3	4
STAD	CBX8 →	+0.659	+3.195	.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,149 associations by consensus.

ZWINT by RTN1 expression — UCEC

Explore this box plot interactively →