RTN1

Across TCGA pan-cancer cohorts, RTN1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RTN1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RTN1 RNA is repressed in tumor relative to normal tissue. In most cancer types RTN1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, KIRC, and THCA are the cancer types where RTN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RTN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−1.040	<.001	10	view →
KIRC	Male	All	+0.691	<.001	10	view →
THCA	Male	All	−1.251	<.001	9	view →
LUSC	Female	II,III,IV	−2.042	<.001	8	view →
LUAD	Female	III,IV	−1.868	<.001	8	view →
LIHC	All	All	+0.439	.001	5	view →
BRCA	Female	All	−0.834	<.001	4	view →
CHOL	Female	All	+1.630	.023	2	view →
READ	All	All	−1.436	<.001	2	view →
UCEC	All	All	−1.141	.006	2	view →
PRAD	All	All	+0.965	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RTN1–COAD

Open the COAD breakdown →