RTN1

Across TCGA patient cohorts, RTN1 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN1-associated genes across cancer lineages are FASN, 14-3-3_beta, and Annexin-1. Each is linked with RTN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RTN1-to-partner and partner-to-RTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by RTN1-low versus RTN1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN1→partner) and Y-score (partner→RTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	FASN →	+0.618	+3.008	.002	.019	3	3
UCEC	14-3-3_beta →	-0.101	-1.673	.003	.040	3	3
UCEC	Annexin-1 →	+0.548	+2.115	.002	.016	3	2
UCEC	ARID1A →	-0.155	-2.999	.016	.034	3	2
UCEC	BRCA2 →	-0.111	-3.126	.013	.018	3	2
UCEC	C-Raf →	+0.145	+1.906	.002	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

FASN by RTN1 expression — COAD

Explore this box plot interactively →