RTL1

Across TCGA cell cohorts, RTL1 mutation is significantly associated with the RNA expression of many other genes, with 382 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTL1-associated genes across cancer lineages are IL36RN, OR6F1, and PSG6. Each is linked with RTL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL1-to-partner and partner-to-RTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL36RN grouped by RTL1-low versus RTL1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL1→partner) and Y-score (partner→RTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL36RN →	+0.115	+2.624	.005	.006	3	2
LUNG_SCLC	OR6F1 →	+0.047	+3.232	<.001	.001	3	2
LUNG_SCLC	PSG6 →	+0.041	+2.938	.001	.003	3	2
LARGE_INTESTINE	KDSR →	+0.772	+3.169	.001	.006	3	2
LARGE_INTESTINE	PRPSAP2 →	+0.650	+3.364	.001	.002	3	2
LARGE_INTESTINE	C12orf60 →	+0.565	+3.064	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 382 associations by consensus.

IL36RN by RTL1 expression — LUNG_SCLC

Explore this box plot interactively →