RTL1

Across TCGA pan-cancer cohorts, RTL1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated RTL1 data layer compared with 7 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RTL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RTL1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and COAD show a favorable association.

KIRC, LIHC, and HNSC are the cancer types where RTL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.429	0.671	<.001	109	view →
LIHC	OS	Tertile	All	0.366	0.577	<.001	98	view →
HNSC	DFS	Median	All	0.653	0.761	.002	65	view →
STAD	OS	Quartile	II,III,IV	0.568	0.745	.006	60	view →
SCLC	OS	Quartile	III,IV	0.602	0.171	.006	47	view →
LUAD	OS	Tertile	All	0.727	0.841	<.001	30	view →
ACC	OS	Median	All	0.398	0.754	.008	29	view →
KIRP	DFS	Quartile	III,IV	0.090	0.473	.003	27	view →
LUSC	DFS	Median	II,III,IV	0.523	0.666	.006	21	view →
SARC	OS	Quartile	All	0.631	0.839	.001	19	view →
UVM	DFS	Tertile	All	0.210	0.761	.011	18	view →
MESO	OS	Quartile	All	0.365	0.607	.016	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

RTL1–KIRC (OS)

Open the KIRC breakdown →