RTEL1-TNFRSF6B

Across TCGA patient cohorts, RTEL1-TNFRSF6B mutation is significantly associated with the RNA expression of many other genes, with 146 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible RTEL1-TNFRSF6B-associated genes across cancer lineages are RNA5SP424, RNY3, and CBX3P8. Each is linked with RTEL1-TNFRSF6B in more than 1 cancer types. Because this analysis shows association rather than direction, both RTEL1-TNFRSF6B-to-partner and partner-to-RTEL1-TNFRSF6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP424 grouped by RTEL1-TNFRSF6B-low versus RTEL1-TNFRSF6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTEL1-TNFRSF6B→partner) and Y-score (partner→RTEL1-TNFRSF6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP424 →	+0.660	+5.242	<.001	.007	3	2
SKCM	RNY3 →	+0.232	+4.513	<.001	.009	3	2
HNSC	CBX3P8 →	+0.054	+4.636	<.001	.006	3	2
HNSC	RN7SL7P →	+0.145	+4.407	.002	.002	3	2
HNSC	RNU1-29P →	+0.178	+4.754	.001	.005	3	2
SKCM	RN7SL734P →	+0.090	+4.771	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 146 associations by consensus.

RNA5SP424 by RTEL1-TNFRSF6B expression — UCEC

Explore this box plot interactively →