RTEL1-TNFRSF6B

Across TCGA pan-cancer cohorts, RTEL1-TNFRSF6B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RTEL1-TNFRSF6B data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RTEL1-TNFRSF6B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RTEL1-TNFRSF6B expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

KIRC, HNSC, and KICH are the cancer types where RTEL1-TNFRSF6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.467	0.725	<.001	121	view →
HNSC	OS	Median	III,IV	0.509	0.292	.007	42	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	35	view →
ACC	DFS	Median	All	0.431	0.775	.001	28	view →
UCEC	OS	Tertile	IV	0.605	0.242	.014	28	view →
COAD	OS	Median	All	0.712	0.888	<.001	24	view →
PRAD	DFS	Tertile	All	0.706	0.871	<.001	22	view →
LGG	DFS	Median	All	0.287	0.464	<.001	20	view →
UVM	DFS	Median	All	0.277	0.675	.004	20	view →
LIHC	DFS	Quartile	All	0.420	0.635	.001	20	view →
MESO	OS	Median	All	0.198	0.364	.019	15	view →
READ	OS	Tertile	All	0.933	0.649	.005	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RTEL1-TNFRSF6B–KIRC (DFS)

Open the KIRC breakdown →