RTEL1-TNFRSF6B

Across TCGA pan-cancer cohorts, RTEL1-TNFRSF6B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RTEL1-TNFRSF6B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RTEL1-TNFRSF6B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RTEL1-TNFRSF6B is over-expressed in tumor.

COAD, KIRC, and HNSC are the cancer types where RTEL1-TNFRSF6B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RTEL1-TNFRSF6B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.444	<.001	12	view →
KIRC	Male	IV	+0.492	<.001	11	view →
HNSC	Male	All	+0.285	<.001	9	view →
STAD	Male	All	+1.017	<.001	8	view →
LIHC	Female	All	+0.228	<.001	8	view →
READ	All	All	+0.835	<.001	7	view →
CHOL	All	All	+0.953	<.001	5	view →
LUAD	Female	All	+0.375	<.001	4	view →
BLCA	All	All	+0.250	.005	4	view →
ESCA	All	All	+1.041	.001	3	view →
KIRP	All	IV	+0.422	.041	2	view →
LUSC	Male	II,III,IV	+0.327	.040	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RTEL1-TNFRSF6B–COAD

Open the COAD breakdown →