RSPO3

Across TCGA patient cohorts, RSPO3 RNA expression is significantly associated with the RNA expression of many other genes, with 15,983 significant associations in total. UVM shows the largest number of these associations.

The most reproducible RSPO3-associated genes across cancer lineages are SYNPO2, LDB2, and FGF7. Each is linked with RSPO3 in more than 29 cancer types. Because this analysis shows association rather than direction, both RSPO3-to-partner and partner-to-RSPO3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RSPO3 versus SYNPO2 in STAD, with a Pearson correlation of 0.79.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO3→partner) and Y-score (partner→RSPO3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SYNPO2 →	+3.218	+2.151	<.001	<.001	3	30
UCS	LDB2 →	+1.680	+2.234	<.001	<.001	3	29
BLCA	FGF7 →	+2.098	+1.434	<.001	<.001	3	29
BLCA	DCN →	+2.826	+1.391	<.001	<.001	3	29
CHOL	TMEM119 →	+2.165	+1.241	<.001	<.001	2	29
UCS	COL14A1 →	+2.767	+2.380	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,983 associations by consensus.

RSPO3 vs SYNPO2 — STAD

Explore this scatter interactively →