RSPO3

Across TCGA pan-cancer cohorts, RSPO3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated RSPO3 data layer compared with 3 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher RSPO3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RSPO3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

UVM, KIRP, and SKCM are the cancer types where RSPO3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.391	0.805	.001	98	view →
KIRP	DFS	Quartile	All	0.793	0.955	<.001	86	view →
SKCM	OS	Median	All	0.826	0.733	<.001	62	view →
BLCA	OS	Tertile	All	0.357	0.616	.010	51	view →
KIRC	DFS	Tertile	III,IV	0.692	0.571	.004	47	view →
LGG	DFS	Tertile	All	0.886	0.765	<.001	41	view →
COAD	DFS	Median	IV	0.250	0.640	.018	19	view →
HNSC	DFS	Tertile	III,IV	0.649	0.513	.022	15	view →
TGCT	DFS	Tertile	All	0.520	0.887	.002	12	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	12	view →
SARC	DFS	Quartile	All	0.717	0.517	.009	9	view →
LUAD	DFS	Quartile	IV	0.158	0.530	.021	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

RSPO3–UVM (DFS)

Open the UVM breakdown →