RSPO1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RSPO1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO1-associated genes across cancer lineages are UBFD1, DCLRE1B, and URB2. Each is linked with RSPO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO1-to-partner and partner-to-RSPO1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RSPO1 versus UBFD1 in LSCC, with a Pearson correlation of -0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO1→partner) and Y-score (partner→RSPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LSCCUBFD1 →-0.668-0.795<.001<.00132
LSCCDCLRE1B →-0.636-0.744<.001.00132
LSCCURB2 →-0.671-0.744.001.00132
LSCCRTCA →-0.673-0.843.008.00132
LSCCOLA1 →-0.576-0.744<.001.00132
LSCCTMEM177 →-0.675-0.884.007.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,216 associations by consensus.

RSPO1 vs UBFD1 — LSCC

Per-sample scatter of RSPO1 vs UBFD1 in LSCC (Pearson r = -0.68).

Explore this scatter interactively →

Exploration