RSPO1

Across TCGA pan-cancer cohorts, RSPO1 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated RSPO1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RSPO1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RSPO1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and MESO show a favorable association.

HNSC, MESO, and LUAD are the cancer types where RSPO1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.679	0.526	<.001	143	view →
MESO	OS	Median	All	0.678	0.404	<.001	105	view →
LUAD	DFS	Median	All	0.579	0.250	<.001	83	view →
KIRP	OS	Quartile	All	0.535	0.811	<.001	69	view →
ACC	OS	Quartile	All	0.210	0.781	<.001	58	view →
ESCA	OS	Median	II,III,IV	0.565	0.335	.002	50	view →
KICH	OS	Tertile	II,III,IV	0.155	0.880	<.001	30	view →
LGG	OS	Tertile	All	0.875	0.728	<.001	29	view →
CESC	OS	Median	All	0.859	0.735	.004	28	view →
CHOL	DFS	Median	All	0.759	0.125	.005	27	view →
UCS	DFS	Quartile	III,IV	0.623	0.132	.011	24	view →
SCLC	DFS	Tertile	II,III,IV	0.192	0.474	.032	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

RSPO1–HNSC (DFS)

Open the HNSC breakdown →