RSPO1

Across TCGA pan-cancer cohorts, RSPO1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RSPO1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RSPO1 RNA is repressed in tumor relative to normal tissue. In most cancer types RSPO1 is over-expressed in tumor, although a few such as HNSC and KIRC show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where RSPO1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSPO1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	II,III,IV	−1.067	<.001	12	view →
KIRC	Female	All	−0.762	<.001	12	view →
COAD	Female	III,IV	−0.800	<.001	11	view →
LUSC	Female	All	−2.658	<.001	9	view →
LUAD	Male	III,IV	−2.516	<.001	9	view →
KICH	All	All	−0.829	<.001	9	view →
BLCA	All	All	−0.726	<.001	9	view →
UCEC	All	III,IV	−5.632	<.001	8	view →
STAD	Female	All	−1.137	.002	7	view →
KIRP	Male	All	−0.389	<.001	7	view →
BRCA	Female	II,III,IV	−1.401	<.001	6	view →
THCA	All	All	+0.584	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RSPO1–HNSC

Open the HNSC breakdown →