RSPO1

Across TCGA patient cohorts, RSPO1 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPO1-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and MEK1. Each is linked with RSPO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO1-to-partner and partner-to-RSPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by RSPO1-low versus RSPO1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO1→partner) and Y-score (partner→RSPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.252	+1.678	.043	.023	3	2
UCEC	eIF4E →	+0.183	+2.584	.023	.010	3	1
UCEC	MEK1 →	+0.474	+2.807	<.001	.003	3	1
UCEC	p27_pT198 →	+0.090	+1.678	.028	.023	3	1
UCEC	Annexin-1 →	+0.466	+3.019	.021	.019	3	1
UCEC	Shc_pY317 →	-0.157	-2.584	.007	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

p62 Lck ligand by RSPO1 expression — UCEC

Explore this box plot interactively →