RSPO1

Across TCGA cell cohorts, RSPO1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RSPO1-associated genes across cancer lineages are GYPA, MOG, and GSG1L2. Each is linked with RSPO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPO1-to-partner and partner-to-RSPO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GYPA grouped by RSPO1-low versus RSPO1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPO1→partner) and Y-score (partner→RSPO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GYPA →	+0.061	+3.793	.002	.007	3	1
LARGE_INTESTINE	MOG →	+0.135	+4.054	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GYPA by RSPO1 expression — LARGE_INTESTINE

Explore this box plot interactively →