RSPH9

Across TCGA patient cohorts, RSPH9 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RSPH9-associated genes across cancer lineages are FOXO3a, MEK1, and Ku80. Each is linked with RSPH9 in more than 1 cancer types. Because this analysis shows association rather than direction, both RSPH9-to-partner and partner-to-RSPH9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by RSPH9-low versus RSPH9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RSPH9→partner) and Y-score (partner→RSPH9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.090	-2.292	.043	.034	3	2
UCEC	MEK1 →	+0.468	+2.584	.003	.010	3	2
UCEC	Ku80 →	+0.257	+1.598	.012	.044	3	1
UCEC	p27_pT198 →	+0.104	+3.000	.026	.036	3	1
UCEC	Tuberin →	+0.268	+2.807	.022	.003	3	1
UCEC	Caspase-8 →	-0.286	-3.558	.009	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

FOXO3a by RSPH9 expression — UCEC

Explore this box plot interactively →