RSPH9

Across TCGA pan-cancer cohorts, RSPH9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of RSPH9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RSPH9 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RSPH9 is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where RSPH9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RSPH9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.194	<.001	12	view →
KICH	All	IV	−0.862	<.001	11	view →
LIHC	All	II,III,IV	+0.510	<.001	9	view →
LUSC	Female	II,III,IV	−1.541	<.001	8	view →
LUAD	Female	All	−1.203	<.001	8	view →
CHOL	All	All	+0.862	<.001	5	view →
BLCA	All	All	−0.233	.003	5	view →
STAD	All	II,III,IV	+0.218	.006	3	view →
UCEC	All	All	−1.356	.001	2	view →
PAAD	All	All	+0.490	.006	2	view →
PRAD	All	All	−0.344	<.001	2	view →
THCA	Male	IV	−0.309	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

RSPH9–KIRC

Open the KIRC breakdown →