RRP1

Across TCGA patient cohorts, RRP1 mutation is significantly associated with the RNA expression of many other genes, with 934 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRP1-associated genes across cancer lineages are RNU6-539P, CLUHP8, and RNU6-193P. Each is linked with RRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRP1-to-partner and partner-to-RRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-539P grouped by RRP1-low versus RRP1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRP1→partner) and Y-score (partner→RRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-539P →	+0.602	+3.026	.001	.004	3	2
SKCM	CLUHP8 →	+0.053	+4.634	<.001	.003	3	2
BRCA	RNU6-193P →	+0.196	+8.057	<.001	.005	3	2
BRCA	CICP6 →	+0.021	+5.096	<.001	.008	3	2
UCEC	SUPV3L1 →	+0.393	+2.818	.009	.001	3	2
UCEC	C1orf50 →	+0.369	+3.201	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 934 associations by consensus.

RNU6-539P by RRP1 expression — COAD

Explore this box plot interactively →