RRM1

Across TCGA patient cohorts, RRM1 protein abundance is significantly associated with the RNA expression of many other genes, with 15,113 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RRM1-associated genes across cancer lineages are CDKN3, MCM4, and ASF1B. Each is linked with RRM1 in more than 9 cancer types. Because this analysis shows association rather than direction, both RRM1-to-partner and partner-to-RRM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RRM1 versus CDKN3 in LUAD, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM1→partner) and Y-score (partner→RRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDKN3 →	+0.879	+0.286	<.001	<.001	3	10
LUAD	MCM4 →	+1.284	+0.536	<.001	<.001	3	10
UCEC	ASF1B →	+0.989	+0.368	<.001	<.001	3	10
BRCA	RAD51AP1 →	+0.828	+0.464	<.001	<.001	3	10
UCEC	KIF20A →	+1.295	+0.562	<.001	<.001	3	10
UCEC	LMNB1 →	+1.005	+0.532	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,113 associations by consensus.

RRM1 vs CDKN3 — LUAD

Explore this scatter interactively →