RRM1

Across TCGA pan-cancer cohorts, RRM1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RRM1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RRM1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRM1 is over-expressed in tumor.

HNSC, KIRC, and LUSC are the cancer types where RRM1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRM1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.978	<.001	11	view →
KIRC	Male	All	+0.454	<.001	11	view →
LUSC	Female	All	+2.054	<.001	9	view →
LIHC	Female	II,III,IV	+1.365	<.001	9	view →
LUAD	Male	All	+0.908	<.001	9	view →
COAD	Male	All	+0.712	<.001	9	view →
STAD	Male	II,III,IV	+0.997	<.001	8	view →
KIRP	All	IV	+0.922	.002	6	view →
BRCA	All	III,IV	+0.748	<.001	6	view →
CHOL	Male	All	+2.373	<.001	5	view →
BLCA	All	All	+0.617	.004	5	view →
ESCA	All	All	+0.764	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RRM1–HNSC

Open the HNSC breakdown →