RRM1

Across TCGA cell cohorts, RRM1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RRM1-associated genes across cancer lineages are CLRN1, GDF3, and TARM1. Each is linked with RRM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RRM1-to-partner and partner-to-RRM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLRN1 grouped by RRM1-low versus RRM1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRM1→partner) and Y-score (partner→RRM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLRN1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	GDF3 →	+0.016	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.016	+4.662	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CLRN1 by RRM1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →