RRAS

Across TCGA patient cohorts, RRAS mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RRAS-associated genes across cancer lineages are eEF2, EGFR_pY1068, and eIF4G. Each is linked with RRAS in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAS-to-partner and partner-to-RRAS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by RRAS-low versus RRAS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAS→partner) and Y-score (partner→RRAS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.473	+2.321	.008	.035	3	1
UCEC	EGFR_pY1068 →	-0.324	-3.169	.010	.019	3	1
UCEC	eIF4G →	+0.329	+2.321	.034	.035	3	1
UCEC	A-Raf_pS299 →	-0.254	-2.321	<.001	.035	3	1
UCEC	Mre11 →	-0.108	-2.321	.012	.035	3	1
UCEC	Smad3 →	+0.188	+3.000	.013	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by RRAS expression — UCEC

Explore this box plot interactively →