RRAS

Across TCGA pan-cancer cohorts, RRAS RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of RRAS’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RRAS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RRAS is over-expressed in tumor, although a few such as BLCA and LUSC show the opposite, repressed pattern.

HNSC, BLCA, and LUSC are the cancer types where RRAS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RRAS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+1.593	<.001	11	view →
BLCA	Male	III,IV	−2.555	<.001	9	view →
LUSC	Female	All	−1.849	<.001	9	view →
LUAD	Male	All	−1.613	<.001	9	view →
KIRC	Male	IV	+1.019	<.001	9	view →
THCA	Male	All	+0.867	<.001	9	view →
KICH	Female	All	−1.716	<.001	8	view →
LIHC	Female	II,III,IV	+1.391	<.001	8	view →
UCEC	All	III,IV	−2.494	<.001	6	view →
BRCA	All	All	−0.869	<.001	6	view →
CHOL	Female	All	+2.013	<.001	3	view →
KIRP	All	III,IV	+0.787	.029	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

RRAS–HNSC

Open the HNSC breakdown →