RRAS

Across TCGA pan-cancer cohorts, RRAS RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RRAS data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher RRAS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RRAS expression acts as an unfavorable survival marker, although some lineages such as ESCA and SKCM show a favorable association.

KIRP, KIRC, and LUSC are the cancer types where RRAS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Quartile	II,III,IV	0.475	0.865	.002	66	view →
KIRC	OS	Quartile	All	0.530	0.714	<.001	64	view →
LUSC	DFS	Quartile	All	0.279	0.544	<.001	61	view →
PAAD	OS	Tertile	All	0.282	0.580	.002	48	view →
ESCA	DFS	Median	III,IV	0.576	0.320	.003	44	view →
GBM	DFS	Median	All	0.173	0.406	<.001	36	view →
SKCM	OS	Median	All	0.414	0.276	<.001	36	view →
LAML	DFS	Tertile	All	0.369	0.720	.003	36	view →
LGG	OS	Tertile	All	0.793	0.949	<.001	35	view →
LUAD	OS	Quartile	All	0.705	0.875	.003	26	view →
SARC	OS	Median	All	0.890	0.781	<.001	20	view →
STAD	DFS	Median	IV	0.321	0.458	.010	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RRAS–KIRP (OS)

Open the KIRP breakdown →