RRAGC

Across TCGA cell cohorts, RRAGC mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RRAGC-associated genes across cancer lineages are TBC1D3, KRTAP4-1, and TFAP2D. Each is linked with RRAGC in more than 1 cancer types. Because this analysis shows association rather than direction, both RRAGC-to-partner and partner-to-RRAGC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by RRAGC-low versus RRAGC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RRAGC→partner) and Y-score (partner→RRAGC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.088	+4.273	<.001	.006	3	1
BLOOD_Lymphoma	KRTAP4-1 →	+0.151	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	TFAP2D →	+0.061	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TBC1D3 by RRAGC expression — LARGE_INTESTINE

Explore this box plot interactively →