RRAGC

Across TCGA pan-cancer cohorts, RRAGC RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RRAGC data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RRAGC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RRAGC expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

LIHC, ACC, and KICH are the cancer types where RRAGC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.452	0.628	<.001	86	view →
ACC	DFS	Median	All	0.213	0.700	<.001	64	view →
KICH	OS	Median	III,IV	0.468	1.000	.001	56	view →
LGG	DFS	Median	All	0.643	0.840	<.001	51	view →
STAD	DFS	Quartile	All	0.577	0.873	.002	47	view →
KIRC	OS	Tertile	All	0.670	0.512	.003	39	view →
MESO	OS	Quartile	IV	0.324	0.845	.006	29	view →
PAAD	DFS	Median	All	0.173	0.367	.010	22	view →
BLCA	DFS	Median	II,III,IV	0.575	0.654	.020	14	view →
COAD	OS	Quartile	IV	0.790	0.447	.020	12	view →
ESCA	DFS	Quartile	II,III,IV	0.179	0.484	.003	9	view →
CHOL	DFS	Tertile	All	0.709	0.282	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RRAGC–LIHC (DFS)

Open the LIHC breakdown →