RPUSD4

Across TCGA patient cohorts, RPUSD4 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPUSD4-associated genes across cancer lineages are IGFBP2, Ku80, and p62 Lck ligand. Each is linked with RPUSD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPUSD4-to-partner and partner-to-RPUSD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by RPUSD4-low versus RPUSD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPUSD4→partner) and Y-score (partner→RPUSD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.887	-2.584	.003	.011	3	1
UCEC	Ku80 →	+0.238	+2.598	.030	.006	3	1
UCEC	p62 Lck ligand →	+0.334	+2.584	.027	.011	3	1
UCEC	SLC1A5 →	-0.508	-2.999	.010	.034	3	1
UCEC	ATM →	-0.435	-2.584	.039	.011	3	1
UCEC	4E-BP1_pT37_T46 →	-0.485	-2.986	.005	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

IGFBP2 by RPUSD4 expression — UCEC

Explore this box plot interactively →