RPUSD4

Across TCGA pan-cancer cohorts, RPUSD4 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated RPUSD4 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher RPUSD4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RPUSD4 expression acts as an unfavorable survival marker, although some lineages such as READ and KIRC show a favorable association.

LIHC, READ, and KIRC are the cancer types where RPUSD4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.403	0.590	<.001	83	view →
READ	DFS	Quartile	II,III,IV	0.681	0.277	.001	78	view →
KIRC	DFS	Median	All	0.719	0.545	<.001	76	view →
ACC	DFS	Median	II,III,IV	0.197	0.635	<.001	65	view →
PAAD	DFS	Median	All	0.197	0.379	.001	34	view →
UVM	DFS	Quartile	All	0.825	0.422	.003	32	view →
LGG	OS	Tertile	All	0.883	0.681	<.001	28	view →
UCEC	DFS	Quartile	III,IV	0.821	0.711	.023	22	view →
LUSC	DFS	Median	III,IV	0.525	0.732	.011	18	view →
GBM	DFS	Quartile	All	0.386	0.151	.011	12	view →
TGCT	DFS	Quartile	All	0.667	0.876	.027	12	view →
MESO	DFS	Tertile	IV	0.179	0.542	.018	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

RPUSD4–LIHC (OS)

Open the LIHC breakdown →