RPUSD1

Across TCGA cell cohorts, RPUSD1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RPUSD1-associated genes across cancer lineages are GHR, NTRK3, and OR14K1. Each is linked with RPUSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPUSD1-to-partner and partner-to-RPUSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHR grouped by RPUSD1-low versus RPUSD1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPUSD1→partner) and Y-score (partner→RPUSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GHR →	+0.514	+3.295	.002	.009	3	1
LARGE_INTESTINE	NTRK3 →	+0.179	+3.415	<.001	.009	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	GKN1 →	+0.031	+2.925	.005	.007	3	1
LARGE_INTESTINE	ABCG4 →	+0.223	+3.451	.008	.005	3	1
LARGE_INTESTINE	GLIS1 →	+0.247	+3.669	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

GHR by RPUSD1 expression — LARGE_INTESTINE

Explore this box plot interactively →