RPSA

Across TCGA patient cohorts, RPSA mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPSA-associated genes across cancer lineages are Erythrocytes, CD8+ Tem, and Plasma cells. Each is linked with RPSA in more than 1 cancer types. Because this analysis shows association rather than direction, both RPSA-to-partner and partner-to-RPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by RPSA-low versus RPSA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPSA→partner) and Y-score (partner→RPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Erythrocytes →	+0.060	+3.191	<.001	.031	3	1
UCEC	CD8+ Tem →	+0.004	+5.066	<.001	.033	3	1
UCEC	Plasma cells →	-0.024	-2.957	.049	.037	2	1
UCEC	Mast cells →	+0.019	+3.042	.040	.018	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

Erythrocytes by RPSA expression — LUAD

Explore this box plot interactively →