RPSA

Across TCGA cell cohorts, RPSA RNA expression is significantly associated with the go_rna of many other GO terms, with 3,415 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RPSA-associated GO terms across cancer lineages are Response to unfolded protein, Protein import into mitochondrial intermembrane space, and tRNA surveillance. Each is linked with RPSA in more than 12 cancer types. Because this analysis shows association rather than direction, both RPSA-to-partner and partner-to-RPSA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to unfolded protein grouped by RPSA-low versus RPSA-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RPSA→partner) and Y-score (partner→RPSA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Response to unfolded protein →	-0.109	-0.746	<.001	<.001	3	12
LUNG_SCLC	Protein import into mitochondrial intermembrane space →	+0.123	+0.899	<.001	<.001	2	13
PANCREAS	tRNA surveillance →	+0.110	+1.017	.003	<.001	3	12
LARGE_INTESTINE	Mitochondrial disulfide relay system →	+0.136	+0.725	<.001	.001	3	12
LARGE_INTESTINE	Cellular response to topologically incorrect protein →	-0.074	-0.823	<.001	<.001	3	11
CNS	Lysosomal lumen acidification →	-0.130	-0.827	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,415 associations by consensus.

Response to unfolded protein by RPSA expression — URINARY_TRACT

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