RPS6KB1

Across TCGA patient cohorts, RPS6KB1 mutation is significantly associated with the RNA expression of many other genes, with 2,581 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6KB1-associated genes across cancer lineages are RN7SL248P, RNVU1-28, and RNA5SP423. Each is linked with RPS6KB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6KB1-to-partner and partner-to-RPS6KB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by RPS6KB1-low versus RPS6KB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6KB1→partner) and Y-score (partner→RPS6KB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.055	+3.022	<.001	.001	3	2
UCEC	RNVU1-28 →	+0.571	+1.635	<.001	.001	3	2
LGG	RNA5SP423 →	+0.353	+7.977	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
UCEC	AQP7P2 →	+0.123	+1.817	<.001	<.001	3	2
COAD	MIR4710 →	+0.713	+4.602	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,581 associations by consensus.

RN7SL248P by RPS6KB1 expression — UCEC

Explore this box plot interactively →