RPS6KB1

Across TCGA pan-cancer cohorts, RPS6KB1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of RPS6KB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where RPS6KB1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RPS6KB1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRP, KIRC, and LUAD are the cancer types where RPS6KB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RPS6KB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.607	<.001	11	view →
KIRC	Female	All	+0.478	<.001	11	view →
LUAD	Male	II,III,IV	+0.897	<.001	9	view →
THCA	All	II,III,IV	−0.459	<.001	9	view →
LIHC	All	II,III,IV	+0.642	<.001	8	view →
KICH	Female	All	−1.135	<.001	7	view →
LUSC	Male	All	+0.434	<.001	6	view →
HNSC	All	All	+0.307	.003	6	view →
CHOL	Male	All	+1.541	<.001	5	view →
BLCA	All	All	+0.352	.011	5	view →
BRCA	All	II,III,IV	+0.286	.003	4	view →
STAD	All	II,III,IV	+0.459	.021	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

RPS6KB1–KIRP

Open the KIRP breakdown →