RPS6

Across TCGA patient cohorts, RPS6 mutation is significantly associated with the RNA expression of many other genes, with 1,280 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RPS6-associated genes across cancer lineages are RN7SL847P, POLR3KP2, and PPP1R26P3. Each is linked with RPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RPS6-to-partner and partner-to-RPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL847P grouped by RPS6-low versus RPS6-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RPS6→partner) and Y-score (partner→RPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL847P →	+0.133	+3.971	<.001	.003	3	2
BLCA	POLR3KP2 →	+0.056	+3.552	<.001	.002	3	2
BLCA	PPP1R26P3 →	+0.008	+4.274	<.001	<.001	3	2
UCEC	RN7SL248P →	+0.059	+3.137	<.001	.005	3	2
UCEC	RNA5SP412 →	+0.508	+1.967	<.001	.005	3	2
SKCM	VN1R66P →	+0.055	+6.469	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,280 associations by consensus.

RN7SL847P by RPS6 expression — BRCA

Explore this box plot interactively →